Abstracting and Indexing

Changes type III collagen expression in human uterosacral ligaments of uterine prolapse

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Original Article

VOLUME: 33 ISSUE: 4

P: 119 - 123

December 2014

Changes type III collagen expression in human uterosacral ligaments of uterine prolapse

Pelviperineology 2014;33(4):119-123

EPPY DARMADI ACHMAD ²

BUDI IMAN SANTOSO ¹

BENNY HASAN PURWARA ²

TYAS PRIYATINI ¹

1. Faculty of Medicine Indonesia University, Division of Urogynecology and Reconstruction, Department of Obstetric and Gynecology Dr. Cipto Mangunkusumo Hospital, Jakarta

2. Faculty of Medicine Universitas Padjadjaran, Division of Urogynecology and Reconstruction, Department of Obstetric and Gynecology Dr. Hasan Sadikin Hospital, Bandung

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ABSTRACT

There are some controversies regarding the content of type III collagen fibers in uterosacral ligaments in pelvic organ prolapse (POP). The role of these fibers are still unclear. This study aims to compare the content of type III collagen fibers in uterosacral ligaments (USl) in patients with or without POP.

This is a cross-sectional analytic study conducted in 23 women with POP from Jakarta Indonesia. The control group were 23 women without POP. The study took place in Dr. Hasan Sadikin Hospital during May-October 2011.

The type III collagen fiber content in USl of women with POP was 50% higher than those in women without POP (p=0.036). In conclusion, the type III collagen fibers content in USl of women with POP is more dense compared with those without POP.

Keywords:

Type III collagen fibers; Pelvic organ prolapse; Uterosacral ligaments.