The purpose of the study is to determine the reaction of different parts of the digestive tract to inflammation in the appendix. It analyzes the medical history of 250 children aged 0.5 to 15 years with suspicion of acute appendicitis (AA). Patients were divided into three groups depending on the method of study. In patients with AA of the first group an increase in the tone of the caecum, ileum and sigmoid was found when using a barium enema. In patients of the second group on anal manometry, basal and reactive pressures were significantly higher in patients operated compared with non-operated children. In patients of the third group, the size of the stomach and its gas bubble with high reliability was less in AA appendicitis compared with unoperated children. Our study shows that local non-specific inflammation in the intestine leads to an increase in the tone of all parts of the digestive tract. This hypothesis allows us to understand the pathological physiology of many diseases. For example, the pain in the epigastric region and vomiting in the early stages of AA occurs because of a sharp reduction in the volume of the stomach. The high doses of Senna cannot be effective, since increased peristalsis is accompanied by an increase in the tone of the anal canal, which prevents defecation. Hypersecretion of hydrochloric acid causes an inflammatory reaction in the esophagus, which can cause pain of different localization, as well as constipation, and diarrhea. Further testing of this hypothesis is needed.
Corresponding Author: LEVIN M.|